ADME

ADME (Absorption, Distribution, Metabolism, Excretion) is an important factor in the drug-ability of a compound. The BioRails platform has been designed specifically to support ADME studies.

The ADME Morphit binders are designed to address the data analysis needs of ADME scientists. They provide support to:

• Read raw data files from instruments such as Mass Spectrometers
• Identify and analyze the peak area data, applying statistics and curve fitting
• Calculate and visualize end point results
• Apply quality control (QC) criteria
• Prepare data for storage in BioRails DM with graphs and charts

Each binder covers a large range of different conditions, such as different species, starting concentrations, cofactors, etc.

ADME is a crucial part of any drug discovery and development effort. Demand for these services can be rate determining to program efforts. Compilation and interpretation of results for consumption by project teams demands clear and concise reporting formats that often take a lot of manual effort to create. BioRails DM offers template reports that, once set up, automate the majority of the reporting effort including:

• Combining results from different assays
• Present graphs and charts of summarized results
• Automatically include protocol information as well as observations from the study
• Reduce the burden on scientists to compile routine reports

High quality reports can be generated in PDF, Word or Excel format.