ADME(T)

Tracking and managing the deliver of ADMET requests can be a real headache especially when resources are limited. BioRails is an ideal environment for scheduling and managing service requests, quickly defining and capturing data from a range of ADMET experiments such as:

• Solubility
• Physicochemical assays like LogP/LogD
• Chemical stability
• Cytochrome P450 enzyme inhibition/induction
• Metabolic stability
• Plasma protein binding
• Permeability PAMPA, Caco-2
• Cytotoxicity/hepatotoxicity
• Metabolite profiling
• Metabolite assessment
• hERG inhibition
• Immunoassays: ELISAs

BioRails flexible protocol design allows data from a range of experiments to be quickly captured and processed. BioRails web services support integration with instrumentation and automation of data capture. BioRails is ideal for both in vitro and in vivo experiments.