Event - BioRails 2017 User Group Meeting

19 October 2017

Date

October 19th and 20th 2017

Venue

H. Lundbeck A/S Ottiliavej 9 | 2500 | Valby | Denmark 

Agenda

Day1: Presentations

9.00 - 9.30 Registration

9.30 - 9.35 Welcome

9.35 - 10.20 Introduction

Andrew Lemon (The Edge)

  • Review of customer deployments and projects
  • Roadmap review

10.20 - 10.40 in vitro Pharmacology workflow

Morten Hentzer (Lundbeck Pharmaceuticals)

The integrated use of BioRails and Morphit for study design, sample registration and data analysis

10.40 - 11.10 Coffee and networking

11.10 - 11.40 Case Study: BioRails inventory - keeping research flowing

Chris Mills (The Edge)

The efficiency of the research workflow is critically dependent on timely access to test materials from inventory. BioRails inventory ensures that demand and supply are at the heart of the process. Designed for today's network R&D environment, it allows organizations to operate with in-house, outsourced (CRO) or hybrid inventory management teams. This case study is based on a recent customer deployment.

11.40 - 11.55 Partner talk - Delivering better design decisions using Star Drop and BioRails

Matt  Segal (Optibrium)

Hear how Optibrium and The Edge worked together to deliver compound design and project reporting to Zoetis.

11.55 - 12.25 Pre-clinical data management, from RS3 to Biorails

Sofia Karlström, Ian Henderson et al. ,Medivir AB

Medivir has recently migrated all its chemical structures (small molecules) and in vitro assay results data from the out-of-date Accelrys RS3 platform into two separate systems, Chemaxon Compound Registration for the chemistry and Biorails for the in vitro assay results. We will describe the challenges encountered in the project and the solutions derived on the way with examples both from in vitro biology and DMPK. Crucial to the project has been the integration with Certara´s D360 and how Biorails data is displayed and analyzed in Certaras D360 will also be shown. 

12.30 - 13.30 Networking Lunch

13.30 - 14.00 Introducing the BioRails 5 platform

Chris Mills (The Edge)

Review of BioRails 5 and why it matters

14.00 - 14.10 Partner talk - D360 at Medivir

Fabian Rauscher (Certara)

Hear how D360 was used to provide project reporting of results from BioRails.

14.10 - 14.20 Partner talk - Chemical Registration at Medivir

Matyas Medzihradszky (Chemaxon)

Hear how Chemaxon and The Edge combined to deliver an integrated solution.

14.20 - 14.50 Morphit 5.0

Ted Hawkins (The Edge)

Review of whats new in Morphit 5.0

14.50 - 15.20 Laboratory Process Optimization

David Hand (Merck KGaA)

In 2010 Merck initiated a laboratory automation and monitoring program. In partnership with Cyprotex we implemented our first generation of systems to support high throughput assays for in vitro NCE eADME. This was initially focused on Microsomal Stability and has since been extended to other assays through numerous iterations using a modular concept and an agile development philosophy. As components of modules become obsolete we replace them and in 2015 we implemented BioRails DM as a solution for Data Analysis and Reporting.
We now want to leverage the lessons we have learned and the concepts we have developed in other business functions. Additionally in our next phase we will replace the test requesting and KPI monitoring components with BioRails PTO to provide a single end to end solution for our business functions.

15.20 - 15.50 Coffee and networking

15.50-16.20 Generic in vivo data capture - from planning to visualization

Allan Grønhøj Hansen (Lundbeck Pharmaceuticals)

At Lundbeck no single tool has existed to follow an in vivo experiment all the way from the initial planning to the final data visualization. This is still the case. Instead we are implementing a workflow centered in BioRails and Morphit, which allows the user address the gap. Starting from TIBCO Spotfire, scientists can plan studies in a combined view for all experiments carried out, internal or external. From there a BioRails experiment can be created, where whatever is planned can be imported in Morphit, and finally depending on which in vivo study is chosen a list of result types is shown to the user for the final data capture. When the experiment is published in BioRails the data is automatically accessible from our assay result system (DDIS), and can be visualized in TIBCO Spotfire.

16.20 - 16.30 Partner Talk - Proteax integration

Jan Holst Jensen (Biochemfusion)

Hear how Biochemfusion and The Edge combined to offer assay workflow support for peptide synthesis and testing.

16.30 - 17.00 Delivering in vitro DM assay services, the challenges and opportunities

Annalisa Pellacani (Aptuit)

As a CRO we offer a full list of Discovery DMPK in vitro assays. In this context, the two main challenges to face are the request  tracking and data integrity. In order to tackle both these issues, in 2016 we adopted Biorails/Morphit. 

Customized protocols have been set up for the most requested Discovery DMPK in vitro assays: protein binding, stability, permeability, clearance, P450 inhibition in HLM and by fluorescence. 

ASSAY REQUEST

Within Biorails assay requests can be entered by selecting test items and assay type and specifying appropriate assay conditions (i.e. matrix, specie, cell type). After request creation, it can be tracked until data delivery: this process allows control over request progression, metrics (number of compounds, number of request by assay or by client) and turn-around time. The whole workflow is tracked ensuring an accurate activity planning and data delivery. 

DATA INTEGRITY

The availability of specific Morphit protocols for each assay allows to directly upload raw data generated by the instruments and to analyze and produce results by a pre-defined calculation template. Results can be reviewed and uploaded to the Biorails database in one go. Minimizing manual data manipulation guarantees a more robust and safer approach to data integrity.In addition, raw data, results and any other required piece of information (i.e.assay protocol, CoA) are stored and signed as in commonly used electronic lab notebook to guarantee long-term data availability and proper data segregation.

17.00-17.10 Round up and event organization
 
Travel to boat pickup by train.

Networking

18.00 - 19.00 Boat tour of Copenhagen

19.00 - 20.00 Drinks and networking

20.00 -  Dinner in Copenhagen

Day 2: Workshops

9.00 - 12.00 Morphit workshop

Ted Hawkins and Jacob Marshal - The Edge

The Morphit workshop is in two sessions.

  • We will explore Morphit reporting and build a screening report from dose response data
  • We will then review the Morphit Starter Pack and highlight all the examples provided and discuss how best to soive common issues and deliver robust Morphit solutions.

No prior knowledge of Morphit is needed, we recommend downloading a trial before the workshop and bringing your laptop.

9.00 - 12.00 BioRails workshop

Lauren Horncastle and Chris Mills  - The Edge

The BioRails workshop is in two sessions.

  • We will show how to create a BioRails workflow to analyse plate-based screening data. You'll learn how the whole request to experiment planning, data analysis and execution workflow is completed with BioRails. Learn how to build a Morphit binder to process and analyze data before saving to BioRails.
  • Process improvement in the absence of specific, relevant metrics is difficult to achieve and impossible to measure. BioRails 5 enables performance monitoring of key processes within the research environment. Learn how to quickly create key performance indicator (KPI) dashboards using the data within BioRails 5 and implement a “review by exception” workflow within your organisation.

12.00 - 12.15 Final comments and thanks 

12.30 End of Meeting

Registration

Register on Everbrite but places are limited so register early.

 

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